Endocrine Abstracts

Risk assessment of chemicals based on no observed adverse effect level (NOAEL) from animal models is normally done for one chemical at a time, but several endocrine disrupting chemicals (EDCs) have been detected in mixtures in humans.For combinations of EDCs with similar mechanism, there is clear evidence that mixture effects can arise at doses around NOAELs. Also, the mixture effects can be predicted based on dose-addition.There i...

Long-lasting and/or delayed reproductive effects of developmental exposure to mixtures of environmental chemicals were investigated in rats. Wistar rats were exposed to mixtures of estrogenic or anti-androgenic endocrine disrupters in pregnancy and lactation, and effects in offspring at 12–18 months of age were studied. The mixture included 13 estrogenic and anti-androgenic chemicals, including phthalates, pesticides, u.v.-filters, bisphenol A, butylparaben and paracetamo...